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Glucagon like peptide-1 receptor (GLP-1R) agonists for the treatment of type 2 diabetes were first
introduced to Europe and the USA in 2005.1 Since then, these compounds have become well-established treatment options in the management of type 2 diabetes.2 GLP-1 R agonists have several attractive features
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Significant events took place in 1975 when Senator Edward Kennedy (Dem-MA)
and members of FDA made allegations against research laboratories in the USA (Searle and Hazelton) related to preclinical research studies.

By January 1986, scientists at Searle had developed a document, Good Laboratory Practice, which was designed to
be used as guidance to evaluate research activities, and submitted it to both FDA and the Pharmaceutical Research and Manufacturers Association of America (PhRMA).
Both sites were subsequently investigated, which revealed serious problems with the conduct of safety studies submitted to the agency.
At the same time, the agency was creating 606 new positions to monitor biological research, and it also began a pilot inspection program
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